Aminophthalocyanine-Mediated Photodynamic Inactivation of Leishmania tropica
نویسندگان
چکیده
منابع مشابه
Amino-phthalocyanine-mediated photodynamic inactivation of Leishmania
21 Photodynamic inactivation (PDT) of Leishmania spp. requires cellular uptake of 22 photosensitizers, e. g. endocytosis of silicon (IV)-phthalocyanines (PC) axially substituted with 23 bulky ligands. We report here that, when substituted with amino-containing ligands, the PCs 24 (PC1 and PC2) were endocytosed and displayed improved potency against Leishmania tropica 25 promastigotes and axenic...
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Root canal disinfection is one of the main factors governing success of endodontic therapy. Antimicrobial photodynamic therapy (aPDT) is presented as a promising antimicrobial therapy that can eliminate microbiota present in infected root canal systems. In this study, a series of experiments investigated the effects of aPDT on cell viability and biofilm degradation ability of endopathogenic mic...
متن کاملMixed mucosal leishmaniasis infection caused by Leishmania tropica and Leishmania
26 Mixed infection by different Leishmania species could explain differences in the clinical 27 course of these infections. On identification of Leishmania parasites from Iranian patients 28 with mucosal leishmaniasis (ML), a patient with both oral and nasal lesions was found to be 29 concomitantly infected with L. tropica and L. major. Mixed infection was identified by PCR 30 amplification of ...
متن کاملLeishmania tropica in children: a retrospective study.
BACKGROUND Limited data are available regarding topical and systemic therapies for Leishmania tropica in children. OBJECTIVE We sought to characterize the clinical presentation and evaluate the efficacy and safety of topical and systemic treatments in pediatric patients infected with L tropica. METHODS A retrospective study was performed on 47 children with L tropica cutaneous leishmaniasis...
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Leishmania tropica is one of the causative agents of cutaneous leishmaniasis (CL), a disfiguring parasitic disease that recently was found to be viscerotropic. In urban areas it is transmitted from infected individuals by the bite of phlebotomine sand flies to naïve persons (anthroponotic CL). In rural areas animals are thought to be the reservoir, but the full life cycle is still under investi...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2016
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01879-15